Pain and its persistence in herpes zoster

Pain. 1996 Oct;67(2-3):241-51. doi: 10.1016/0304-3959(96)03122-3.


The nature and duration of pain associated with herpes zoster is highly variable. This review of research on pain in acute herpes zoster and postherpetic neuralgia (PHN) explores those observations relevant to the definition and pathogenesis of PHN and the design of treatment trials. A model for the pathogenesis of PHN is presented, which gains support from studies of risk factors. Several directions for future research are identified.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Herpes Zoster / complications
  • Herpes Zoster / physiopathology*
  • Humans
  • Neuralgia / etiology
  • Neuralgia / physiopathology
  • Pain / physiopathology*