Efficacy and safety of azithromycin versus lymecyline in the treatment of genital chlamydial infections in women

Scand J Infect Dis. 1996;28(5):451-4. doi: 10.3109/00365549609037938.


To compare the clinical and microbiological efficacy of azithromycin in curing chlamydial infections in women with that of lymecycline, and with a view of the possibility of minimizing the problem of compliance by means of single-dose administration, 146 women with culture-positive Chlamydia trachomatis infections were randomly assigned to treatment with a 1 g bolus dose of azithromycin or a 10-day course of lymecycline 300 mg twice daily. Clinical and microbiological evaluations were performed and adverse effects monitored at check-ups after 15-35 and 40-65 days. Of the 146 patients enrolled in the study, 120 were evaluable. At the second check-up, C. trachomatis was found to have been eradicated in all patients in both treatment groups. Of the 51 patients who had clinical signs and symptoms of genital infection at enrolment, 96% (22/23) of those in the azithromycin group were considered cured (n = 18) or improved (n = 4), as compared with 100% (28/28) of those considered cured (n = 22) or improved (n = 6) in the lymecycline group. Adverse events related, or possibly related, to treatment were reported by 16 (21.6%) of the lymecycline group, but by only 6 (8.3%) of the azithromycin group. The 2 drugs were comparable with regard to microbiological and clinical efficacy in the treatment of genital chlamydial infection in women. The markedly lower rate of side-effects associated with azithromycin may be a feature conducive to patient compliance.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / adverse effects
  • Azithromycin / therapeutic use*
  • Chlamydia Infections / drug therapy*
  • Chlamydia Infections / microbiology
  • Chlamydia trachomatis / isolation & purification*
  • Double-Blind Method
  • Female
  • Genital Diseases, Female / drug therapy*
  • Genital Diseases, Female / microbiology
  • Humans
  • Lymecycline / adverse effects
  • Lymecycline / therapeutic use*
  • Recurrence
  • Safety
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Lymecycline
  • Azithromycin