The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome

Genomics. 1996 Nov 15;38(1):84-6. doi: 10.1006/geno.1996.0596.


The tuberous sclerosis 2 (TSC2) and polycystic kidney disease 1 (PKD1) genes are adjacent on human chromosome 16p13.3 and form part of a conserved synteny group with mouse chromosome 17. We have determined that the PKD1 gene is evolutionarily conserved, single copy, and linked to TSC2 in the Fugu genome. A short cosmid contig has been identified containing both genes based on hybridization, exon trapping, and random sequence data. In addition sequences homologous to the somatostatin type V receptor (SSTR5) were identified 5' to PKD1, defining a larger syntenic region, as this gene has also been mapped to human chromosome 16p13.3. As in mammalian genomes, the Fugu TSC2 and PKD1 genes are adjacent in a tail-to-tail orientation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fishes, Poisonous / genetics*
  • Genes, Dominant
  • Genome
  • Humans
  • Mice
  • Proteins / genetics*
  • Receptors, Somatostatin / genetics*
  • Repressor Proteins / genetics*
  • TRPP Cation Channels
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins


  • Proteins
  • Receptors, Somatostatin
  • Repressor Proteins
  • TRPP Cation Channels
  • TSC2 protein, human
  • Tsc2 protein, mouse
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins
  • polycystic kidney disease 1 protein
  • somatostatin receptor 5