High-flux hemodialysis postpones clinical manifestation of dialysis-related amyloidosis

Am J Nephrol. 1996;16(6):484-8. doi: 10.1159/000169048.


Amyloidosis due to the retention of beta 2-microglobulin (beta 2-MG) is a frequent complication of hemodialysis (HD). Significant amounts of beta 2-MG can be removed from the body by highly permeable HD membranes, whereas conventional low-flux membranes are impermeable for the molecule. In a prospective and controlled study we investigated whether high-flux HD could delay the onset of dialysis-related amyloidosis (DRA). Twenty patients treated with cuprophane low-flux HD membranes were matched for age and previous time on HD either to continue their HD regimen or to receive HD treatment with high-flux polysulfone membranes. For 6 years each patient was examined for manifestations of DRA once a year or upon individual needs, additionally, serum beta 2-MG levels were monitored. After 6 years of follow-up no clinical signs of DRA were found in any of the patients dialyzed with high-flux polysulfone membranes, whereas 8/10 of the conventionally dialyzed patients had CTS and/or osteoarticular lesions. Serum levels of beta 2-MG were significantly reduced in patients treated with high-flux polysulfone membranes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Amyloidosis / diagnosis
  • Amyloidosis / etiology*
  • Bone Cysts / diagnosis
  • Bone Cysts / etiology
  • Carpal Tunnel Syndrome / etiology
  • Cellulose / analogs & derivatives
  • Female
  • Humans
  • Joint Diseases / diagnosis
  • Joint Diseases / etiology
  • Male
  • Membranes, Artificial
  • Middle Aged
  • Polymers
  • Prospective Studies
  • Renal Dialysis / adverse effects
  • Renal Dialysis / instrumentation*
  • Renal Dialysis / methods
  • Sulfones
  • beta 2-Microglobulin / analysis


  • Membranes, Artificial
  • Polymers
  • Sulfones
  • beta 2-Microglobulin
  • polysulfone P 1700
  • Cellulose
  • cuprammonium cellulose