Effect of prenatal aluminium lactate exposure on conditioned taste aversion and passive avoidance task in the rat

J Appl Toxicol. 1996 Nov-Dec;16(6):529-32. doi: 10.1002/(SICI)1099-1263(199611)16:6<529::AID-JAT392>3.0.CO;2-S.

Abstract

Pregnant SPRD rats were injected s.c. daily with 2.45, 4.9 and 9.8 mg kg-1 aluminium lactate or distilled water on gestational days 7-15. Gestational aluminium treatment had no effect either on litter size or the body weight of pups on postnatal day 1 but it decreased postnatal weight gain resulting in significantly lower body weight at weaning (postnatal day 22). It had no effect on the acquisition of a conditioned taste aversion, but in a passive avoidance task the learning ability of pups of dams given the top dose of aluminium was impaired.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum / toxicity*
  • Aluminum Compounds / toxicity*
  • Animals
  • Aversive Therapy
  • Avoidance Learning / drug effects*
  • Conditioning, Psychological
  • Female
  • Lactates / toxicity*
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rats
  • Rats, Inbred Strains
  • Taste / drug effects*

Substances

  • Aluminum Compounds
  • Lactates
  • Aluminum
  • aluminum lactate