Analyses of reported family history of glaucoma: a preliminary investigation. The Barbados Eye Study Group

Ophthalmic Epidemiol. 1996 Dec;3(3):135-41. doi: 10.3109/09286589609080119.

Abstract

This study investigated the self-reported family history of open-angle glaucoma (OAG) among 4,314 black participants in the Barbados Eye Study (BES), which was based on a random sample of Barbados-born citizens between 40 and 84 years of age. Data collection included Humphrey perimetry, fundus photography, various ophthalmic and other measurements and a comprehensive interview, including family history. Results showed that participants with OAG and previous OAG treatment reported more family history; maternal history was reported twice as often as paternal history. In persons without previous OAG treatment, those with newly diagnosed OAG reported more sibling history (Odds Ratio = 4.5). The Statistical Analysis for Genetic Epidemiology (S.A.G.E.) system was used to test the transmission models for OAG in a subset of 1,048 families (5,806 individuals) with the most complete self-reported family information. The S.A.G.E. results are consistent with the existence of a major dominant allele for OAG. These results should be viewed as promising, but preliminary, since they are based on self-reported data. More definitive information is currently being collected by the Barbados Family Study of Open-angle Glaucoma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Bias
  • Blacks
  • Family Health
  • Female
  • Glaucoma, Open-Angle / epidemiology*
  • Glaucoma, Open-Angle / genetics*
  • Humans
  • Hypertension / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Self Disclosure