Purpose: To report the rare occurrence of choroidal melanoma in an African-American albino.
Methods: A 68-year-old African-American man with oculocutaneous albinism developed an amelanotic choroidal mass in his left eye. A transvitreal fine-needle aspiration biopsy was performed to confirm the diagnosis, and the patient was treated with iodine 125 plaque radiotherapy.
Results: The cytology of the needle biopsy showed spindle cells with nuclear atypia and prominent nucleoli. The cells showed positive immunoreactivity for HMB-45, supporting the diagnosis of choroidal melanoma.
Conclusion: To our knowledge, this is the first reported case of a choroidal melanoma occurring in an African-American albino.