Contralateral lung injury associated with single-lung ischemia-reperfusion injury

Ann Thorac Surg. 1996 Dec;62(6):1644-9. doi: 10.1016/s0003-4975(96)00810-7.


Background: There have been very few studies on the effect of single-lung ischemia-reperfusion on the function of the contralateral lung. This study was designed to clarify the effect.

Methods: Fifteen mongrel dogs were divided into two groups. In group 1 (n = 7), the left lung was subjected to ischemia without ventilation for 90 minutes, and then reperfused. In group II (n = 8), the lung was not subjected to ischemia, and was ventilated during the 90-minute ischemia of group I. Arterial blood gas, hemodynamics, extravascular lung water, and airway pressure were measured. Pulmonary biopsy was performed to evaluate adenine nucleotide levels. The protein concentration and phosphorous concentration of phospholipids in bronchoalveolar lavage fluid were measured.

Results: Group I, with perfusion and ventilation of the right lung alone, was significantly inferior to group II with respect to arterial blood gas, right pulmonary compliance, extravascular lung water of the right lung, and the protein concentration in the bronchoalveolar lavage fluid of the right lung after the 90-minute period.

Conclusions: These results indicate that 90 minutes of warm ischemia and reperfusion of the left lung caused deterioration of not only the left but also contralateral right pulmonary function.

MeSH terms

  • Adenine Nucleotides / metabolism
  • Animals
  • Bronchoalveolar Lavage Fluid
  • Dogs
  • Extravascular Lung Water / metabolism
  • Hemodynamics
  • Lung / blood supply*
  • Lung / metabolism
  • Lung Compliance
  • Lung Transplantation
  • Oxygen / blood
  • Reperfusion Injury / metabolism
  • Reperfusion Injury / physiopathology*
  • Vascular Resistance


  • Adenine Nucleotides
  • Oxygen