Overwhelming postsplenectomy infection

Infect Dis Clin North Am. 1996 Dec;10(4):693-707. doi: 10.1016/s0891-5520(05)70322-6.


The incidence of overwhelming sepsis in asplenic patients is low. It carries, however, an unacceptably high morbidity rate and mortality rate. The risk of development is related to the age of the patient as well as the duration since and the reason for splenectomy. It may also occur in functionally hyposplenic states. The rapidly lethal clinical course demands intense efforts toward prevention by both physician and patient, rapid recognition within the initial medical setting, and aggressive intervention with broad-spectrum antibiotics and other supportive measures.

Publication types

  • Review

MeSH terms

  • Humans
  • Incidence
  • Infections / diagnosis
  • Infections / epidemiology
  • Infections / etiology*
  • Infections / microbiology
  • Infections / mortality
  • Infections / therapy
  • Splenectomy / adverse effects*