Structure of nucleosome core particles of chromatin

Nature. 1977 Sep 1;269(5623):29-36. doi: 10.1038/269029a0.


Cystals have been obtained on nucleosome cores and analysed by X-ray diffraction and electron microscopy. The core is a flat particle of dimensions about 110 X 110 X 57 A, somewhat wedge shaped, and strongly divided into two 'layers', consistent with the DNA being wound into about 1 3/4 turns of a flat superhelix of a pitch about 28 A. The organisation of the DNA can be correlated with the results to enzyme digestion studies. A change in the screw of the DNA double helix on nucleosome formation can be deduced.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromatin / ultrastructure*
  • Crystallization
  • DNA*
  • Deoxyribonucleases / metabolism
  • Histones*
  • Liver / ultrastructure
  • Microscopy, Electron
  • Molecular Weight
  • Nucleic Acid Conformation*
  • Protein Binding
  • Rats
  • X-Ray Diffraction


  • Chromatin
  • Histones
  • DNA
  • Deoxyribonucleases