Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients

Lung Cancer. 1996 Nov;15(3):355-66. doi: 10.1016/0169-5002(95)00598-6.


The genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung / ethnology*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / mortality
  • China / epidemiology
  • DNA Probes / chemistry
  • DNA, Neoplasm / analysis*
  • Female
  • Genes, myc / genetics*
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Isoenzymes / genetics*
  • Lung Neoplasms / ethnology*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / mortality
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Risk Factors
  • Sex Factors
  • Surveys and Questionnaires
  • Survival Rate


  • Biomarkers, Tumor
  • DNA Probes
  • DNA, Neoplasm
  • Isoenzymes
  • Glutathione Transferase