Cestocidal activity of Acacia auriculiformis

J Helminthol. 1996 Jun;70(2):171-2. doi: 10.1017/s0022149x00015340.

Abstract

The cestocidal activity of Acacia auriculiformis was evaluated using rats each harbouring a single adult worm of Hymenolepis diminuta. The ethanol extract (300 mg/kg/day) and the saponins (200 mg/kg/day) obtained from the funicles of A. auriculiformis, were administered orally to two groups each of 10 rats, respectively, on day 20 after oral inoculation with a single cysticercoid of H. diminuta. Adult worms were expelled within 5 days from rats treated with the ethanol extract and within 3 days from those treated with saponins. No appreciable side effects were observed in the treated rats.

MeSH terms

  • Acacia / chemistry*
  • Administration, Oral
  • Animals
  • Anticestodal Agents / administration & dosage
  • Anticestodal Agents / pharmacology
  • Anticestodal Agents / therapeutic use*
  • Feces / parasitology
  • Hymenolepiasis / drug therapy*
  • Hymenolepis / drug effects
  • Male
  • Parasite Egg Count
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Saponins / pharmacology
  • Saponins / therapeutic use*

Substances

  • Anticestodal Agents
  • Plant Extracts
  • Saponins