Massive osteolysis (Gorham-Stout syndrome) in the maxillofacial region: an unusual manifestation

Int J Oral Maxillofac Surg. 1996 Oct;25(5):376-8. doi: 10.1016/s0901-5027(06)80035-4.


An unusual case of massive osteolysis affecting the left side of the mandible, the maxilla, the zygoma, and the orbit is reported. The disease extended over a period of 25 years. The special feature of this case is that there were, before the osteolysis appeared, enlargement and sclerosis of the maxillofacial bones reaching up to the middle cranial fossa. Histopathologic examination of the affected mandible revealed that the bone was replaced by fibrous tissue.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Facial Bones / diagnostic imaging
  • Facial Bones / pathology*
  • Fibrosis
  • Follow-Up Studies
  • Humans
  • Mandibular Diseases / diagnostic imaging
  • Mandibular Diseases / pathology
  • Maxillary Diseases / diagnostic imaging
  • Maxillary Diseases / pathology
  • Orbital Diseases / diagnostic imaging
  • Orbital Diseases / pathology
  • Osteolysis, Essential / diagnostic imaging
  • Osteolysis, Essential / pathology*
  • Osteosclerosis / diagnostic imaging
  • Osteosclerosis / pathology
  • Radiography
  • Skull / pathology
  • Zygoma / diagnostic imaging
  • Zygoma / pathology