Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide

Transplant Proc. 1996 Dec;28(6):3088-91.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Cells, Cultured
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Intracellular Membranes / enzymology
  • Isoxazoles / pharmacology*
  • Leflunomide
  • Lymphocyte Activation / drug effects*
  • Lymphocytes / drug effects
  • Lymphocytes / enzymology*
  • Lymphocytes / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • Microsomes / enzymology
  • Mitochondria / enzymology
  • Molecular Sequence Data
  • Oxidoreductases / antagonists & inhibitors*
  • Oxidoreductases / chemistry*
  • Oxidoreductases Acting on CH-CH Group Donors*
  • Peptide Fragments / chemistry
  • Rats
  • Sequence Homology, Amino Acid
  • Spleen / immunology

Substances

  • Immunosuppressive Agents
  • Isoxazoles
  • Peptide Fragments
  • Oxidoreductases
  • Oxidoreductases Acting on CH-CH Group Donors
  • dihydroorotate dehydrogenase
  • Leflunomide