To obtain information about the psychological needs of wheelchair users, 45 subjects participating in a university-based drop-in physical activity centre and outpatient rehabilitation program completed the Personal Styles Inventory and the Ways of Coping Inventory. Three groups of subjects were formed, differentiated by etiology for their disability. Results suggested that subjects with brain injury possessed the most limited coping resources. Subjects with multiple sclerosis were highest of the three groups in the frequency of utilization of emotional coping, they also revealed a fundamentally introverted and stability-based personality style. Subjects with spinal cord injuries utilized a predominantly Problem-solving means of coping: and they revealed a basic personality style characterized as extroverted and stable. The findings suggest that disease process (perhaps through common preexisting psychological characteristics, the nature of the onset and progression of the disease process, and/or tissue damage) may modify the ability to adapt and cope with the need to use a wheelchair. The nature of psychological support to be offered should reflect not only the use of a wheelchair but also the underlying personality and its modification by the nature of the disease process.