Islet cell and glutamic acid decarboxylase antibodies and heat-shock protein 65 responses in children with newly diagnosed insulin-dependent diabetes mellitus

Immunol Lett. 1996 Jan;49(1-2):123-6. doi: 10.1016/0165-2478(95)02493-x.

Abstract

Islet cell antibodies (ICA) were detected in 66% and glutamic acid decarboxylase (GAD) antibodies in 64% of children (n = 47) with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Fifteen percent of the patients had neither GAD nor ICA antibodies. Responses to mycobacterial heat-shock protein 65 (Hsp65) were detected in all patients. There was a significant correlation between anti-GAD antibodies and proliferation of peripheral blood mononuclear cells to Hsp65, and between ICA and antibodies to Hsp65.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / biosynthesis*
  • Autoantibodies / immunology*
  • Bacterial Proteins*
  • Chaperonin 60
  • Chaperonins / immunology*
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / immunology*
  • Glutamate Decarboxylase / immunology*
  • Humans
  • Infant
  • Isoantibodies / biosynthesis*
  • Lymphocyte Activation

Substances

  • Antibodies, Bacterial
  • Autoantibodies
  • Bacterial Proteins
  • Chaperonin 60
  • Isoantibodies
  • heat-shock protein 65, Mycobacterium
  • islet cell antibody
  • Chaperonins
  • Glutamate Decarboxylase