Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: a serial analysis

J Neuroimmunol. 1996 May;66(1-2):147-51. doi: 10.1016/0165-5728(96)00026-4.

Abstract

We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4+ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.

MeSH terms

  • Adult
  • Antigens, CD / metabolism*
  • Brain / pathology
  • CD4-Positive T-Lymphocytes / metabolism*
  • Cell Adhesion Molecules / blood*
  • Cell Separation
  • Female
  • Flow Cytometry
  • Gadolinium DTPA
  • Humans
  • Lymphocyte Activation*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / physiopathology*
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium DTPA