Peptide T and glucose metabolism in AIDS dementia complex

J Nucl Med. 1996 Jul;37(7):1177-80.


AIDS dementia complex (ADC) is the most common presenting neurologic manifestation of human immunodeficiency virus (HIV)-1 infection. We report FDG-PET studies in a 39-year-old man who had ADC and completed a 12-wk treatment protocol with 1.2 mg/day of intranasal peptide T, one before and one after 12 wk of treatment with peptide T. Peptide T is an octapeptide under investigation for treatment of ADC patients. Values of rCMRglc were converted to Z scores using the mean and standard deviation of values of rCMRglc in three HIV-seronegative matched controls, each of which was studied twice, at the beginning and end of a 12-wk interval. Thirty-five of 60 regions assayed showed Z scores with absolute values > or = 3 (considered abnormal) in the baseline study. Regions with high absolute values of Z scores were located in subcortical areas and in the limbic system, and to a lesser degree in the frontal, temporal and parietal lobes. Thirty-four of these 35 regions showed remission (decrease in the absolute values of Z scores) after treatment. Only one region showed no improvement in the second study. Three regions with absolute values of Z scores < 3 in the baseline study manifested Z scores with magnitudes > or = 3 in the second study. These preliminary observations suggest that functional neuroimaging techniques provide a useful tool in the evaluation of the response to treatment in ADC patients.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / diagnostic imaging*
  • AIDS Dementia Complex / drug therapy*
  • AIDS Dementia Complex / metabolism
  • Adult
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Case-Control Studies
  • Deoxyglucose / analogs & derivatives*
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Humans
  • Male
  • Peptide T / therapeutic use*
  • Time Factors
  • Tomography, Emission-Computed*


  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Peptide T
  • Deoxyglucose
  • Glucose