Decreased CD5+ B cells during the acute phase of Kawasaki disease

Yonsei Med J. 1996 Feb;37(1):52-8. doi: 10.3349/ymj.1996.37.1.52.

Abstract

We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p < 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p < 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.

MeSH terms

  • Acute Disease
  • B-Lymphocytes / immunology*
  • CD5 Antigens / analysis*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • Mucocutaneous Lymph Node Syndrome / physiopathology
  • Reference Values

Substances

  • CD5 Antigens