HLA class II genes associated with REM sleep behavior disorder

Ann Neurol. 1996 Feb;39(2):261-3. doi: 10.1002/ana.410390216.


Twenty-five white men with rapid eye movements (REM) sleep behavior disorder, but without narcolepsy, underwent HLA class II antigen typing: 84% (N=21) were DQwl (DQB1*05,06) positive (28% [N=7] were DR2 positive); DQB1*0501 (N=9) and DQB1*0602 (N=7) were the most common phenotypes. The 84% DQwl rate in men with REM sleep behavior disorder was significantly greater (p=0.015) than the 56% DQwl rate found in a local white comparison group (N=66), and was greater than the 39 to 66% DQwl rates published for 12 white groups (N=40-418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class II genes.

Publication types

  • Comparative Study

MeSH terms

  • Electromyography
  • Genes, MHC Class II*
  • HLA Antigens / analysis
  • HLA Antigens / classification
  • HLA-DQ Antigens / analysis
  • Humans
  • Male
  • Middle Aged
  • Reaction Time
  • Sleep / physiology
  • Sleep Wake Disorders / genetics*
  • Sleep Wake Disorders / immunology
  • Sleep, REM*


  • HLA Antigens
  • HLA-DQ Antigens
  • HLA-DQ1 antigen