Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta
- PMID: 8968022
- DOI: 10.1016/s8756-3282(96)00305-5
Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta
Abstract
The oim strain of mice is one of several rodent models that exhibit an osteogenesis imperfecta (OI) phenotype. These mice have a mutation in the gene encoding alpha-2 chain of type I procollagen that prevents proper assembly of this propeptide with alpha-1 propeptides. Homozygous oim mice experience multiple bone fractures under standard laboratory animal housing conditions and are representative of moderate to severe forms of OI. Because fractures are not typically experienced by heterozygous oim mice, they have not been studied extensively. The present studies show that the organization of cortical bone is deficient in heterozygotes, exhibiting a morphology intermediate to specimens from homozygotes and wild-type mice. The biomechanical properties of femurs isolated from heterozygous oim mice are also intermediate to homozygotes and wild-type mice when tested in four-point bending. Although it is not possible to distinguish visually between heterozygous oim and wild-type mice, the quality and biomechanical properties of bone in heterozygotes is significantly reduced by twelve weeks of age. Heterozygous oim mice are useful as a model for a mild form of OI.
Similar articles
-
Dietary fluoride restriction does not alter femoral biomechanical strength in col1a2-deficient (oim) mice with type I collagen glomerulopathy.J Nutr. 2010 Oct;140(10):1752-6. doi: 10.3945/jn.109.120261. Epub 2010 Aug 19. J Nutr. 2010. PMID: 20724489
-
Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim).Bone. 2001 Nov;29(5):453-7. doi: 10.1016/s8756-3282(01)00594-4. Bone. 2001. PMID: 11704498
-
Sclerostin antibody reduces long bone fractures in the oim/oim model of osteogenesis imperfecta.Bone. 2019 Jul;124:137-147. doi: 10.1016/j.bone.2019.04.011. Epub 2019 Apr 30. Bone. 2019. PMID: 31051315
-
Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Osteoporos Int. 2016. PMID: 26179666 Free PMC article.
-
OIM and related animal models of osteogenesis imperfecta.Connect Tissue Res. 1995;31(4):265-8. doi: 10.3109/03008209509010820. Connect Tissue Res. 1995. PMID: 15612365 Review.
Cited by
-
Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.Mol Med. 2024 May 21;30(1):66. doi: 10.1186/s10020-024-00838-3. Mol Med. 2024. PMID: 38773377 Free PMC article.
-
Extra-Skeletal Manifestations in Osteogenesis Imperfecta Mouse Models.Calcif Tissue Int. 2024 Apr 19. doi: 10.1007/s00223-024-01213-4. Online ahead of print. Calcif Tissue Int. 2024. PMID: 38641703
-
The recombinant BMP-2 loaded silk fibroin microspheres improved the bone phenotype of mild osteogenesis imperfecta mice.PeerJ. 2023 Oct 30;11:e16191. doi: 10.7717/peerj.16191. eCollection 2023. PeerJ. 2023. PMID: 37927786 Free PMC article.
-
Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice.Dis Model Mech. 2022 Sep 1;15(9):dmm049428. doi: 10.1242/dmm.049428. Epub 2022 Sep 28. Dis Model Mech. 2022. PMID: 36106514 Free PMC article.
-
Up-regulated IL-17 and Tnf signaling in bone marrow cells of young male osteogenesis imperfecta mice.PeerJ. 2022 Aug 23;10:e13963. doi: 10.7717/peerj.13963. eCollection 2022. PeerJ. 2022. PMID: 36032950 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
