NaCl and LiCl efficacy in the induction of aversion for quinine and saccharin solutions immediately following injection

Pharmacol Biochem Behav. 1977 May;6(5):567-9. doi: 10.1016/0091-3057(77)90118-6.

Abstract

Rats 24-hr water deprived were injected IP with a fixed amount (10 ml/kg) of solution of various concentrations of LiCl and NaCl in dosage ranges which in previous experiments either increased or had no effect on water intake. Intake of 0.01% QHCl decreased with increasing concentrations of both NaCl and LiCl. On a molar basis, LiCl was more effeictive. LiCl also produced an aversion to a palatable solution, 0.1% sodium saccharin; however, NaCl produced no aversion over the dosage range which can be tolerated by the animals.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Dose-Response Relationship, Drug
  • Female
  • Lithium / pharmacology*
  • Motor Activity / drug effects
  • Quinine / pharmacology*
  • Rats
  • Saccharin / pharmacology*
  • Sodium Chloride / pharmacology*
  • Time Factors
  • Water Deprivation

Substances

  • Sodium Chloride
  • Lithium
  • Quinine
  • Saccharin