Immunologic parameters in cord blood indicating early-onset sepsis

Biol Neonate. 1996;70(4):206-12. doi: 10.1159/000244366.


Different immunologic parameters were measured in cord blood to test their usefulness in the early diagnosis of early onset sepsis. Cord blood levels of circulating intercellular adhesion molecule-1 (cICAM-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly elevated in septic compared to nonseptic neonates. No significant difference between either population was seen for cord blood C3a and elastase-alpha 1-proteinase inhibitor complex (E alpha 1 PI). Measured concentrations of cICAM-1, IL-6 and IL-8 in fetal and maternal blood did not correlate, indicating that the neonate's response to sepsis is clearly different from the mother. Our data suggest that cord blood measurements of cICAM-1, IL-6 and IL-8 might be useful in identifying neonates with early-onset sepsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Escherichia coli Infections
  • Fetal Blood / immunology*
  • Haemophilus Infections
  • Haemophilus influenzae
  • Humans
  • Infant, Newborn
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-6 / analysis
  • Interleukin-8 / analysis
  • Sepsis / diagnosis*
  • Sepsis / immunology*


  • Interleukin-6
  • Interleukin-8
  • Intercellular Adhesion Molecule-1