Virus-cell and cell-cell fusion

Annu Rev Cell Dev Biol. 1996;12:627-61. doi: 10.1146/annurev.cellbio.12.1.627.


Significant progress has been made in elucidating the mechanisms of viral membrane fusion proteins; both those that function at low, as well as those that function at neutral, pH. For many viral fusion proteins evidence now suggests that a triggered conformational change that exposes a previously cryptic fusion peptide, along with a rearrangement of the fusion protein oligomer, allows the fusion peptide to gain access to the target bilayer and thus initiate the fusion reaction. Although the topologically equivalent process of cell-cell fusion is less well understood, several cell surface proteins, including members of the newly described ADAM gene family, have emerged as candidate adhesion/fusion proteins.

Publication types

  • Review

MeSH terms

  • Cell Membrane*
  • Membrane Fusion*
  • Recombinant Fusion Proteins
  • Viral Fusion Proteins*
  • Viruses*


  • Recombinant Fusion Proteins
  • Viral Fusion Proteins