Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite

Drug Metab Dispos. 1996 Dec;24(12):1401-3.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aryl Hydrocarbon Hydroxylases*
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Mephenytoin / analogs & derivatives
  • Mephenytoin / analysis
  • Mephenytoin / metabolism
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism*
  • Phenytoin / analysis
  • Phenytoin / metabolism*
  • Stereoisomerism
  • Steroid 16-alpha-Hydroxylase*
  • Steroid Hydroxylases / metabolism*

Substances

  • Phenytoin
  • 4-hydroxymephenytoin
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Steroid Hydroxylases
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Steroid 16-alpha-Hydroxylase
  • Mephenytoin