Review article: methotrexate in gastroenterology--dangerous villain or simply misunderstood?

Aliment Pharmacol Ther. 1996 Dec;10(6):851-8. doi: 10.1046/j.1365-2036.1996.70244000.x.


Methotrexate has a place in the treatment of an increasing number of diseases. Its emerging role in the treatment of primary biliary cirrhosis and inflammatory bowel disease still requires further evaluation. Its toxicity profile is wide and is affected by a variety of factors. Hepatotoxicity from long-term use in patients with psoriasis and rheumatoid arthritis holds particular concern for the physician. Appropriate monitoring guidelines for hepatotoxicity can only be made after careful evaluation of available data and consideration of cost-to-benefit models.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / drug therapy
  • Chemical and Drug Induced Liver Injury*
  • Gastroenterology / methods
  • Gastrointestinal Agents / adverse effects*
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Liver Cirrhosis, Biliary / drug therapy
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use*
  • Psoriasis / drug therapy


  • Gastrointestinal Agents
  • Methotrexate