Directing alternative splicing: cast and scenarios

Trends Genet. 1996 Nov;12(11):472-8. doi: 10.1016/0168-9525(96)10037-8.


Recent progress in the study of alternative RNA splicing indicates that the interaction of RNA-binding proteins with specific target elements modulates splice site recognition and spliceosome assembly. The identity of splicing signals, the presence of modulating elements and differences in the distribution of RNA-binding proteins are key determinants involved in the tissue-specific regulation of splice site selection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Drosophila / genetics
  • Gene Expression Regulation
  • Mammals
  • Models, Genetic*
  • Spliceosomes / genetics