The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites

Gene. 1996 Nov 28;181(1-2):233-5. doi: 10.1016/s0378-1119(96)00490-8.

Abstract

11 beta-Hydroxysteroid dehydrogenase type 1 (E.C. 1.1.1.146) (11 beta-HSD 1) is a key enzyme in the metabolism of glucocorticoids, catalysing their interconversion with physiologically inert 11-keto metabolites. To identify transcription factors which may be involved in the regulation of expression of mouse 11 beta-HSD 1 we have isolated and sequenced the 5' flanking DNA to 900 bp upstream from the major transcription start site.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenases
  • Animals
  • Base Sequence
  • Binding Sites
  • DNA / metabolism*
  • Gene Expression Regulation, Enzymologic
  • Hydroxysteroid Dehydrogenases / genetics*
  • Mice
  • Molecular Sequence Data
  • Rats
  • Transcription Factors / metabolism*

Substances

  • Transcription Factors
  • DNA
  • Hydroxysteroid Dehydrogenases
  • 11-beta-Hydroxysteroid Dehydrogenases

Associated data

  • GENBANK/X92186