The prevalence of anti-receptor autoantibodies in the sera of patients with dilated cardiomyopathy has been previously demonstrated. This article will briefly review the distribution of autoantibodies against a series of G-protein-coupled cardiovascular receptors such as human beta 1 and beta 2 adrenoceptors, alpha 1 adrenoceptors, M2 muscarinic acetylcholine receptors and angiotensin II-I (AT1) receptors in a well-defined population of patients with dilated cardiomyopathy from Japan.