[99mTc]tricine: a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates

Bioconjug Chem. Sep-Oct 1995;6(5):635-8. doi: 10.1021/bc00035a020.

Abstract

The stannous reduction of [99mTc]pertechnetate in the presence of tricine results in the formation of the new labeling precursor complex [[99m-Tc]tricine. This complex has improved efficacy for the 99mTc labeling of hydrazinonicotinate-modified IgG compared to [99mTc]glucoheptonate. FAB mass spectral analysis of the product formed by the reaction of [TcOCl4](-1) with tricine indicates the formation of [TcO(tricine x 2H)2](-1).

Publication types

  • Comparative Study

MeSH terms

  • Cross-Linking Reagents
  • Glycine / analogs & derivatives*
  • Glycine / chemistry
  • Humans
  • Immunoglobulin G / chemistry
  • Niacinamide / analogs & derivatives
  • Organotechnetium Compounds / chemistry*
  • Proteins / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Succinimides
  • Sugar Acids / chemistry

Substances

  • Cross-Linking Reagents
  • Immunoglobulin G
  • Organotechnetium Compounds
  • Proteins
  • Succinimides
  • Sugar Acids
  • succinimidyl 6-hydrazinonicotinate
  • Niacinamide
  • technetium Tc 99m gluceptate
  • Glycine
  • tricine