[The effect of a low dose of piracetam on the activity of the dopaminergic system in the rat striatum]

Eksp Klin Farmakol. Mar-Apr 1996;59(2):6-8.
[Article in Russian]

Abstract

The low-dose effect (100 mg/kg, intraperitoneally) of the nootropic drug pyracetam on some DA-ergic neurochemical parameters of the rat striatum, as well as on the locomotion activity of rats were studied using the "open-field" test. It was shown that pyracetam (l mM) in vitro increases the K(+)-stimulated (28 mM) DA release from the perfused isolated striatum to 148 +/- 14 pmole/mg tissue compared to the control animals: 101 +/- 10 pmole /mg (p < 0.05, Student's t-test). Pyracetam in a dose of 100 mg/kg increased the DA level and decreased the 5-HT level in the striatum homogenates: DA- to 121% and 5-HT-to 81% (p < 0.05), respectively. The content of DOPAC, HVA and 5-HIAA in the tissue remained the same. In addition to the mentioned effects pyracetam promoted the locomotion activity of rats in the "open field" -putative behavioral marker of the striatum DA-ergic function. Thus pyracetam is capable of modifying the DA-ergic activity of the rat striatum, thus stimulating the neuromediator release.

MeSH terms

  • Animals
  • Corpus Striatum / drug effects*
  • Corpus Striatum / physiology
  • Dopamine / metabolism
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Male
  • Motor Activity / drug effects
  • Nootropic Agents / administration & dosage*
  • Piracetam / administration & dosage*
  • Rats
  • Rats, Wistar
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine / physiology
  • Time Factors

Substances

  • Nootropic Agents
  • Receptors, Dopamine
  • Dopamine
  • Piracetam