Sympathetic ophthalmia following cyclocryotherapy is extremely rare. The authors report a case of sympathetic ophthalmia after cyclocryotherapy for neovascular glaucoma due to central retinal vein occlusion. Histopathologic examination of the exciting eye showed features of significant sympathetic ophthalmia along with migration of uveal pigments to the limbal conjunctiva with lymphocytic infiltration around it, thereby indicating probable etiopathogenesis.