Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21

FEBS Lett. 1996 Dec 2;398(2-3):135-40. doi: 10.1016/s0014-5793(96)01189-1.


Four exons of a human homologue of a yeast cell division cycle gene (MCM6/mis5, which is thought to encode a DNA replication licensing factor) have been identified 3.3 kb upstream from the start of transcription of the intestinal lactase gene on human chromosome 2q21, initially by similarity to a rat 'intestinal crypt-cell replication factor'. RT-PCR analysis shows, that unlike lactase, MCM6 is not restricted in its tissue distribution and does not show person-to-person variation in the level of expression in adult intestine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Cell Cycle
  • Cell Cycle Proteins / biosynthesis
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2*
  • Cloning, Molecular
  • DNA Replication
  • Fungal Proteins / genetics*
  • Gene Expression
  • Genes, Fungal
  • Humans
  • Intestine, Small / metabolism
  • Lactase
  • Minichromosome Maintenance Complex Component 6
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces pombe Proteins*
  • beta-Galactosidase / genetics*


  • Cell Cycle Proteins
  • Fungal Proteins
  • Schizosaccharomyces pombe Proteins
  • Lactase
  • beta-Galactosidase
  • MCM6 protein, human
  • Minichromosome Maintenance Complex Component 6
  • mcm6 protein, S pombe

Associated data

  • GENBANK/U67281
  • GENBANK/U67282
  • GENBANK/U67283
  • GENBANK/U67284