Dominant inhibition of intercellular communication by two chimeric connexins

Clin Exp Pharmacol Physiol. 1996 Dec;23(12):1062-7. doi: 10.1111/j.1440-1681.1996.tb01170.x.


1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Communication / drug effects*
  • Connexins / genetics*
  • Connexins / pharmacology*
  • Electrophysiology
  • Fibrosarcoma
  • Mice
  • Microinjections
  • Oocytes / physiology
  • Recombinant Fusion Proteins / pharmacology*
  • Transfection
  • Tumor Cells, Cultured
  • Xenopus


  • Connexins
  • Recombinant Fusion Proteins