Malignant hyperthermia-like reaction secondary to ingestion of hops in five dogs

J Am Vet Med Assoc. 1997 Jan 1;210(1):51-4.


Five dogs, 4 of which were Greyhounds, suffered adverse effects secondary to the ingestion of spent hops. Mean time to onset of clinical signs was 3 hours, and clinical signs included marked hyperthermia, restlessness, panting, vomiting, signs of abdominal pain, and seizures. Four of the 5 dogs died despite aggressive therapeutic measures, and there was rapid onset of rigor mortis in 3. The overrepresentation of Greyhounds, coupled with the clinical signs, was suggestive of a malignant hyperthermia-like response to the ingestion of hops. It also is possible that hops contain an uncoupler of oxidative phosphorylation.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dog Diseases / etiology*
  • Dogs
  • Female
  • Male
  • Malignant Hyperthermia / etiology
  • Malignant Hyperthermia / veterinary*
  • Plant Poisoning / complications
  • Plant Poisoning / etiology
  • Plant Poisoning / veterinary*
  • Plants, Edible*
  • Plants, Medicinal*