Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 144 (4), 1835-50

Classification of European mtDNAs From an Analysis of Three European Populations


Classification of European mtDNAs From an Analysis of Three European Populations

A Torroni et al. Genetics.


Mitochondrial DNA (mtDNA) sequence variation was examined in Finns, Swedes and Tuscans by PCR amplification and restriction analysis. About 99% of the mtDNAs were subsumed within 10 mtDNA haplogroups (H, I, J, K, M, T, U, V, W, and X) suggesting that the identified haplogroups could encompass virtually all European mtDNAs. Because both hypervariable segments of the mtDNA control region were previously sequenced in the Tuscan samples, the mtDNA haplogroups and control region sequences could be compared. Using a combination of haplogroup-specific restriction site changes and control region nucleotide substitutions, the distribution of the haplogroups was surveyed through the published restriction site polymorphism and control region sequence data of Caucasoids. This supported the conclusion that most haplogroups observed in Europe are Caucasoid-specific, and that at least some of them occur at varying frequencies in different Caucasoid populations. The classification of almost all European mtDNA variation in a number of well defined haplogroups could provide additional insights about the origin and relationships of Caucasoid populations and the process of human colonization of Europe, and is valuable for the definition of the role played by mtDNA backgrounds in the expression of pathological mtDNA mutations.

Similar articles

See all similar articles

Cited by 215 PubMed Central articles

See all "Cited by" articles


    1. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1158-62 - PubMed
    1. Hum Biol. 1993 Jun;65(3):359-85 - PubMed
    1. Am J Phys Anthropol. 1994 Feb;93(2):189-99 - PubMed
    1. Am J Hum Genet. 1993 Sep;53(3):591-608 - PubMed
    1. Genomics. 1993 Jul;17(1):171-84 - PubMed

Publication types


LinkOut - more resources