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. 1996 Dec 13;87(6):1001-14.
doi: 10.1016/s0092-8674(00)81795-x.

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

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Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

T Serafini et al. Cell. .

Abstract

During nervous system development, spinal commissural axons project toward floor plate cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein made by floor plate cells, can attract spinal commissural axons and repel trochlear axons in vitro, but its role in vivo is unknown. Netrin-1 deficient mice exhibit defects in spinal commissural axon projections that are consistent with netrin-1 guiding these axons. Defects in several forebrain commissures are also observed, suggesting additional guidance roles for netrin-1. Trochlear axon projections are largely normal, predicting the existence of additional cues for these axons, and evidence is provided for a distinct trochlear axon chemorepellent produced by floor plate cells. These results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo.

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