A case-control study of prosthetic implants and selected chronic diseases

Ann Epidemiol. 1996 Nov;6(6):530-40. doi: 10.1016/s1047-2797(96)00109-3.


We examined the association between prosthetic nonbreast implants and selected malignant neoplasms, connective tissue disorders, and neurologic diseases. We conducted a case-control study from an insurance claims database. We selected controls who had diseases for which no association with implants have been claimed or reported. Data were analyzed using both tabular and polytomous regression analysis methods, including methods to account for the large number of comparisons. All analyses exhibited positive associations between implants (both silicone and metal) and neurologic conditions, especially idiopathic progressive neuropathy and Meniere syndrome, as well as the expected associations with arthritic conditions. There also was an unexpected negative association between metal implants and brain tumors. In conclusion, further studies of prosthetic implants and neurologic diseases appear warranted. These studies should obtain medical histories to control for possible confounding effects of drug treatments associated with implant surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Chronic Disease
  • Connective Tissue Diseases / epidemiology
  • Connective Tissue Diseases / etiology*
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasms / epidemiology
  • Neoplasms / etiology*
  • Nervous System Diseases / epidemiology
  • Nervous System Diseases / etiology*
  • Odds Ratio
  • Prostheses and Implants / adverse effects*
  • Prosthesis Failure
  • Reference Values
  • Regression Analysis
  • Sex Distribution