Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient with SLE

Clin Exp Rheumatol. 1996 Nov-Dec;14(6):695-7.

Abstract

The CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is expressed on activated antigen presenting cells, but its expression on peripheral blood mononuclear cells is very low. Here we report a patient with untreated SLE whose peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Antigen-Presenting Cells / immunology*
  • B7-1 Antigen / immunology*
  • Child
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Interferon-gamma / therapeutic use
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / therapy
  • Prednisolone / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • B7-1 Antigen
  • Interferon-gamma
  • Prednisolone