Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia

J Neurol Sci. 1996 Nov;143(1-2):57-9. doi: 10.1016/s0022-510x(96)00065-2.

Abstract

We describe a patient with autoimmune insulin-dependent diabetes whose original symptoms of trunk stiffness and rigidity of the abdomen were followed three years later by a pancerebellar syndrome. An autoantibody (autoAb) against GABAergic neurons was found in the patient's serum and cerebrospinal fluid (CSF); on Western blot, this autoAb recognized a 64-kDa antigen of cerebellar protein. The detection of this antibody in a case with ataxia suggests that a spectrum of different neurological diseases may be observed in patients harbouring anti-GABAergic neuron autoAb and supports the concept that factors other than autoAb contribute to the clinical presentation of these disorders.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Ataxia / immunology*
  • Autoantibodies / cerebrospinal fluid*
  • Cerebellum / chemistry
  • Female
  • Humans
  • Immunoblotting
  • Immunoglobulin G / cerebrospinal fluid
  • Immunohistochemistry
  • Middle Aged
  • Rats
  • Rats, Sprague-Dawley
  • Stiff-Person Syndrome / immunology*
  • gamma-Aminobutyric Acid / analysis
  • gamma-Aminobutyric Acid / immunology*

Substances

  • Autoantibodies
  • Immunoglobulin G
  • gamma-Aminobutyric Acid