The mammalian brain rsec6/8 complex

Neuron. 1996 Dec;17(6):1209-19. doi: 10.1016/s0896-6273(00)80251-2.


rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Carrier Proteins*
  • Cells, Cultured
  • Hippocampus / cytology
  • Hippocampus / metabolism
  • Membrane Proteins / metabolism
  • Neurons / metabolism
  • Peptide Mapping
  • Precipitin Tests
  • Proteins / genetics
  • Proteins / isolation & purification
  • Proteins / metabolism*
  • Qa-SNARE Proteins
  • Rats
  • Subcellular Fractions / metabolism
  • Tissue Distribution


  • Carrier Proteins
  • Exoc3 protein, rat
  • Exoc4 protein, rat
  • Membrane Proteins
  • Proteins
  • Qa-SNARE Proteins