hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues

Biochim Biophys Acta. 1996 Dec 11;1309(3):200-4. doi: 10.1016/s0167-4781(96)00177-7.


We have cloned a 420 bp cDNA from a human fetal brain cDNA library in lambda encoding the human homologue of a DSIP-immunoreactive leucine zipper protein (DIP) isolated from porcine brain. The derived human protein (hDIP) shares a significant sequence identity with parts of the murine TSC-22 and Drosophila shs, both proteins which are discussed as functioning as transcriptional regulators. A similar role of hDIP is partially confirmed by the results of an RT-PCR analysis, demonstrating the widespread distribution of the protein among different human tissues.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Brain / embryology
  • Cloning, Molecular
  • Conserved Sequence
  • DNA, Complementary / chemistry
  • Delta Sleep-Inducing Peptide / chemistry*
  • Drosophila / metabolism
  • Gene Expression Regulation / genetics
  • Humans
  • Leucine Zippers / genetics*
  • Mice
  • Molecular Sequence Data
  • Proteins / chemistry*
  • Repressor Proteins*
  • Sequence Analysis
  • Sequence Homology, Amino Acid
  • Transcription, Genetic / genetics*


  • DNA, Complementary
  • Proteins
  • Repressor Proteins
  • TSC22D1 protein, human
  • Tgfb1i4 protein, mouse
  • Delta Sleep-Inducing Peptide

Associated data

  • GENBANK/Z50781