Effects of acute D-CPPene on mesoaccumbens dopamine responses to nicotine in the rat

Eur J Pharmacol. 1996 Dec 5;316(2-3):153-6. doi: 10.1016/s0014-2999(96)00792-3.


Acute administration of the NMDA receptor antagonist, D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid; 2 mg/kg), abolished (P < 0.01) the sensitised mesoaccumbens dopamine response to nicotine (0.4 mg/kg) measured using in vivo microdialysis, but not the increased locomotor activity, observed in rats pretreated with nicotine prior to the test day. D-CPPene enhanced (P < 0.01) the mesoaccumbens dopamine response, but not the locomotor response, to acute nicotine given to drug-naive rats. The data suggest that sensitised mesoaccumbens dopamine responses to nicotine involve co-stimulation of NMDA receptors but that this effect is not closely related to sensitisation of the locomotor response to the drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dopamine / metabolism*
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Locomotion / drug effects*
  • Male
  • Microdialysis
  • Nicotine / pharmacology*
  • Piperazines / pharmacology*
  • Rats
  • Rats, Sprague-Dawley


  • Excitatory Amino Acid Antagonists
  • Piperazines
  • SDZ EAA 494
  • Nicotine
  • Dopamine