Abstract
Streptomyces globisporus 1912 produces anthracycline-like antibiotics inhibiting the growth of gram-positive bacteria. 6-7 compounds can be separated from crude culture extract by means of thin-layer chromatography. The compound with Rf 0.33 can act as the antitumor antibiotic against Guérin carcinoma of rats.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / biosynthesis
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / therapeutic use*
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Carcinoma / drug therapy*
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Drug Screening Assays, Antitumor
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Female
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Neoplasm Transplantation
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Rats
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Remission Induction
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Streptomyces / metabolism*
Substances
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Antibiotics, Antineoplastic