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, 275 (5297), 213-5

Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

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Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

H Markram et al. Science.

Abstract

Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.

Comment in

  • The year of the dendrite.
    Sejnowski TJ. Sejnowski TJ. Science. 1997 Jan 10;275(5297):178-9. doi: 10.1126/science.275.5297.178. Science. 1997. PMID: 8999546 No abstract available.

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