Successful glucocorticoid treatment for patients with abnormal autoimmunity on in vitro fertilization and embryo transfer

J Assist Reprod Genet. 1996 Nov;13(10):776-81. doi: 10.1007/BF02066497.

Abstract

Purpose: To analyze the effects of glucocorticoid treatment for patients with abnormal autoimmunity on IVF-ET outcomes, low-dose predonisolone or dexamethasone was administered in 51 IVF-ET cycles of 41 patients with positive antinuclear antibody (ANA), anti-DNA antibody, and/or lupus anticoagulant (LAC). Rates of clinical pregnancy and implantation in these patients were compared with those in 48 cycles without corticosteroid therapy. Autoantibody-negative patients were also treated with IVF-ET combined with (29 cycles) or without (57 cycles) glucocorticoid administration, and the pregnancy and implantation rates were investigated.

Results: Without glucocorticoid treatment, the pregnancy rate per cycle and implantation rate per embryo in antibody-positive patients were 10.4 and 3.8%, respectively. Significant increases in pregnancy (35.3%) and implantation (13.2%) rates were observed with corticosteroid treatment. In antibody-negative patients, the rates of pregnancy and implantation showed no significant differences with versus without the glucocorticoid administration.

Conclusions: Our results indicate that because autoimmune abnormalities may be at least one cause of implantation failure following IVF-ET, the combined use of low-dose corticosteroid can be effective for autoantibody-positive women.

MeSH terms

  • Adult
  • Antibodies, Antinuclear / immunology
  • Autoantibodies / analysis
  • Autoantibodies / immunology
  • Autoimmune Diseases / drug therapy*
  • Autoimmunity / immunology
  • Dexamethasone / therapeutic use
  • Embryo Transfer
  • Female
  • Fertilization in Vitro*
  • Glucocorticoids / therapeutic use*
  • Humans
  • Lupus Coagulation Inhibitor / immunology
  • Prednisolone / therapeutic use
  • Pregnancy
  • Pregnancy Rate

Substances

  • Antibodies, Antinuclear
  • Autoantibodies
  • Glucocorticoids
  • Lupus Coagulation Inhibitor
  • Dexamethasone
  • Prednisolone