The occurrence of pulmonary embolisms in patients having circulating lupus anticoagulant has been reported. Lupus anticoagulant has been noticed in association with autoimmune diseases and early-onset severe preeclampsia. We report a case of Sjögren's syndrome with circulating lupus anticoagulant in a patient who developed a pulmonary embolism and severe preeclampsia at 29 weeks of gestation.