Review
doi: 10.1016/s0968-0004(96)20027-1.
Three-part inventions: intracellular signaling and induced proximity
Affiliations
- PMID: 8987395
- DOI: 10.1016/s0968-0004(96)20027-1
Item in Clipboard
Review
Three-part inventions: intracellular signaling and induced proximity
Trends Biochem Sci.
1996 Nov.
Free article
Abstract
Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.
Similar articles
-
Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases.Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):361-85. Biochem J. 1996. PMID: 8670043 Free PMC article. Review. No abstract available.
-
Peptidylproline cis/trans isomerases.Prog Biophys Mol Biol. 1995;63(1):67-118. doi: 10.1016/0079-6107(94)00009-x. Prog Biophys Mol Biol. 1995. PMID: 7538221 Review. No abstract available.
-
Simulations of enzymic reactions.Biochem Soc Trans. 1996 Feb;24(1):247-54. doi: 10.1042/bst0240247. Biochem Soc Trans. 1996. PMID: 8674677 Review. No abstract available.
-
Nuclear magnetic resonance methods for studying protein-ligand complexes.Methods Enzymol. 1994;239:717-39. doi: 10.1016/s0076-6879(94)39027-4. Methods Enzymol. 1994. PMID: 7530321 Review. No abstract available.
-
The chemistry of signal transduction.Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):56-61. doi: 10.1073/pnas.92.1.56. Proc Natl Acad Sci U S A. 1995. PMID: 7529414 Free PMC article. Review.
Cited by
-
Engineering proteins for custom inhibition of Ca(V) channels.Physiology (Bethesda). 2009 Aug;24:210-8. doi: 10.1152/physiol.00010.2009. Physiology (Bethesda). 2009. PMID: 19675352 Free PMC article. Review.
-
Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons.J Negat Results Biomed. 2013 Sep 8;12:13. doi: 10.1186/1477-5751-12-13. J Negat Results Biomed. 2013. PMID: 24010830 Free PMC article.
-
A method to rapidly induce organelle-specific molecular activities and membrane tethering.Methods Mol Biol. 2014;1174:231-45. doi: 10.1007/978-1-4939-0944-5_16. Methods Mol Biol. 2014. PMID: 24947386 Free PMC article.
-
Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems.J Cell Sci. 2014 Mar 15;127(Pt 6):1151-60. doi: 10.1242/jcs.099994. J Cell Sci. 2014. PMID: 24634506 Free PMC article. Review.
-
Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues.Chem Sci. 2022 Oct 25;13(44):13122-13131. doi: 10.1039/d2sc04662h. eCollection 2022 Nov 16. Chem Sci. 2022. PMID: 36425501 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
