Evidence for a Ras/Ral Signaling Cascade

Trends Biochem Sci. 1996 Nov;21(11):438-41. doi: 10.1016/s0968-0004(96)10058-x.

Abstract

It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Phospholipase D / metabolism*
  • Signal Transduction*
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
  • rac GTP-Binding Proteins
  • rap GTP-Binding Proteins
  • ras Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • Phospholipase D
  • GTP-Binding Proteins
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
  • rac GTP-Binding Proteins
  • rap GTP-Binding Proteins
  • ras Proteins