Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes

Clin Pharmacol Ther. 1996 Dec;60(6):645-50. doi: 10.1016/S0009-9236(96)90212-X.

Abstract

Cefpirome is a cephalosporin eliminated primarily by kidneys that requires dosage reduction in patients with renal failure. The pharmacokinetic parameters were studied in 10 patients with end-stage renal disease who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12.2 +/- 5.4 micrograms/ml and peak serum concentrations of 99.6 +/- 82.1 micrograms/ml. After 3 1/2 hours of hemodialysis with polysulfone high-flux membranes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half-life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.

MeSH terms

  • Adult
  • Aged
  • Cephalosporins / administration & dosage
  • Cephalosporins / blood
  • Cephalosporins / pharmacokinetics*
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Infusions, Intravenous
  • Kidney Failure, Chronic / therapy
  • Male
  • Membranes, Artificial*
  • Middle Aged
  • Polymers*
  • Renal Dialysis / methods*
  • Sulfones*

Substances

  • Cephalosporins
  • Membranes, Artificial
  • Polymers
  • Sulfones
  • polysulfone P 1700
  • cefpirome